Boom attended the AKI Art Academy in Enschede, Netherlands, where she studied graphic design.She then worked at the Dutch Government Publishing and Printing Office in The Hague for five years before founding Irma Boom Office in Amsterdam in 1991. She works both nationally and internationally in the cultural and commercial sectors; her clients include the Rijksmuseum in Amsterdam, Wiel Arets, Chanel, Paul Fentener van Vlissingen, Inside Outside, Museum Boijmans, Zumtobel, Ferrari, Vitra, NAi Publishers, and Camper. Since 1992 she has been a critic at Yale University in the USA, and has both lectured and given workshops worldwide. Her work has received many awards, and she is the youngest person to have ever been honored with a Gutenberg Prize.